Pragmatic, adaptive clinical trials: Is 2020 the dawning of a new age?

Given the high case fatality rate of SARS-CoV-2, for which there is no cure and no vaccine, clinicians are forced to make decisions about how best to manage patients with limited high-quality evidence to guide treatment. Traditional randomized controlled trials provide strong experimental evidence,...

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Bibliographic Details
Main Authors: Westyn Branch-Elliman, Lisa Soleymani Lehmann, William E. Boden, Ryan Ferguson, Paul Monach
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Contemporary Clinical Trials Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865420300983