A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently and is protective in the cotton rat model.

Bibliographic Details
Main Authors: Aimin Tang, Zhifeng Chen, Kara S. Cox, Hua-Poo Su, Cheryl Callahan, Arthur Fridman, Lan Zhang, Sangita B. Patel, Pedro J. Cejas, Ryan Swoyer, Sinoeun Touch, Michael P. Citron, Dhanasekaran Govindarajan, Bin Luo, Michael Eddins, John C. Reid, Stephen M. Soisson, Jennifer Galli, Dai Wang, Zhiyun Wen, Gwendolyn J. Heidecker, Danilo R. Casimiro, Daniel J. DiStefano, Kalpit A. Vora
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12137-1

Internet

https://doi.org/10.1038/s41467-019-12137-1

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