HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.

HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.

We have previously shown that the HIV protease inhibitor lopinavir-ritonavir (LPV-RTV) and the antibiotic trimethoprim sulfamethoxazole (TMP-SMX) inhibit Plasmodium liver stages in rodent malarias and in vitro in P. falciparum. Since clinically relevant levels are better achieved in the non-human-pr...

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Bibliographic Details
Main Authors: Charlotte V Hobbs, Jillian Neal, Solomon Conteh, Liam Donnelly, Jingyang Chen, Kennan Marsh, Lynn Lambert, Sachy Orr-Gonzalez, Jessica Hinderer, Sara Healy, William Borkowsky, Scott R Penzak, Sumana Chakravarty, Stephen L Hoffman, Patrick E Duffy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4079689?pdf=render

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http://europepmc.org/articles/PMC4079689?pdf=render

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