Gene-specific MicroRNA antagonism protects against HIV Tat and TGF-β-mediated suppression of CFTR mRNA and function

Gene-specific MicroRNA antagonism protects against HIV Tat and TGF-β-mediated suppression of CFTR mRNA and function

Background: MicroRNAs play an important role in health and disease. TGF-β signaling, upregulated by HIV Tat, and in chronic airway diseases and smokers upregulates miR-145-5p to suppress cystic fibrosis transmembrane conductance regulator (CFTR). CFTR suppression in chronic airway diseases like Cyst...

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Bibliographic Details
Main Authors: R.K. Dutta, S. Chinnapaiyan, M.J. Santiago, I. Rahman, H.J. Unwalla
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
MicroRNA
HIV
Gene therapy
CRISPR
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221008738

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http://www.sciencedirect.com/science/article/pii/S0753332221008738

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