Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans.

Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans.

Interactions between HLA class I molecules and killer-cell immunoglobulin-like receptors (KIR) control natural killer cell (NK) functions in immunity and reproduction. Encoded by genes on different chromosomes, these polymorphic ligands and receptors correlate highly with disease resistance and susc...

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Bibliographic Details
Main Authors: Paul J Norman, Jill A Hollenbach, Neda Nemat-Gorgani, Lisbeth A Guethlein, Hugo G Hilton, Marcelo J Pando, Kwadwo A Koram, Eleanor M Riley, Laurent Abi-Rached, Peter Parham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3814319?pdf=render

Internet

http://europepmc.org/articles/PMC3814319?pdf=render

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