Design and analysis of stably integrated reporters for inducible transgene expression in human T cells and CAR NK-cell lines

Design and analysis of stably integrated reporters for inducible transgene expression in human T cells and CAR NK-cell lines

Abstract Background Cytotoxic activity of T- and NK-cells can be efficiently retargeted against cancer cells using chimeric antigen receptors (CARs) and rTCRs. In the context of solid cancers, use of armored CAR T- and NK cells secreting additional anti-cancer molecules such as cytokines, chemokines...

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Bibliographic Details
Main Authors: Sergey V. Kulemzin, Daria A. Matvienko, Artur H. Sabirov, Arpine M. Sokratyan, Daria S. Chernikova, Tatyana N. Belovezhets, Anton N. Chikaev, Aleksandr V. Taranin, Andrey A. Gorchakov
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Medical Genomics
Subjects:
Chimeric antigen receptor
Cancer
Reporter
Inducible promoter
NK cell lines
Online Access:http://link.springer.com/article/10.1186/s12920-019-0489-4

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http://link.springer.com/article/10.1186/s12920-019-0489-4

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