Hydrogen Peroxide Stimulates the LPS-induced Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

Hydrogen Peroxide Stimulates the LPS-induced Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production and BH4 synthesis, and also ROS release. This stu...

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Bibliographic Details
Main Authors: Shiota Kazuhiro, Shimizu Shumchi, Ishii Masakazu, Yamamoto Shinichiro, Iwasaki Michiko, Yamamoto Toshinori, Kiuchi Yuji
Format: Article
Language:English
Published: De Gruyter 2002-02-01
Series:Pteridines
Subjects:
hydrogen peroxide
tetrahydrobiopterin
endothelial cells
rat
lipopolysacharide
Online Access:https://doi.org/10.1515/pteridines.2002.13.1.21

Internet

https://doi.org/10.1515/pteridines.2002.13.1.21

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