Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury

Growth Differentiation Factor 5 Improves Neurogenesis and Functional Recovery in Adult Mouse Hippocampus Following Traumatic Brain Injury

The aim of this study was to investigate the therapeutic effect of growth differentiation factor 5 (GDF-5) on traumatic brain injury (TBI) in mice. We utilized a controlled cortical impact to establish a mouse TBI model, and then stereotaxically administered 25 or 100 ng GDF-5 into the bilateral hip...

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Bibliographic Details
Main Authors: Hongjie Wu, Jing Li, Dongxiao Xu, Qiansheng Zhang, Tao Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Neurology
Subjects:
growth differentiation factor 5
hippocampus
neurogenesis
traumatic brain injury
functional recovery
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00592/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.00592/full

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