Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer’s disease

Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer’s disease

Alzheimer’s disease (AD), the most common form of dementia, disproportionately affects women in both prevalence and severity. This increased vulnerability to AD in women is strongly associated with age-related ovarian hormone loss and apolipoprotein E 4 allele (ApoE4), the most important genetic ris...

Full description

Bibliographic Details
Main Authors: Xu eHou, Samuel A. Adeosun, Qinli eZhang, Brett eBarlow, Melissa eBrents, Baoying eZheng, Junming eWang
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
Amyloid
Alzheimer's disease
female
learning and memory
sex differences
ApoE4
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00207/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00207/full

Similar Items