Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry

Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry

Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a faulty autoimmune response. Recently, it was reported that some human carbonic anhydrases (CAs) isoforms are overexpressed in inflamed synovium of RA patients. New CA inhibitors (CAIs) incorporating CA-binding moiety and the cyc...

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Bibliographic Details
Main Authors: Marta Menicatti, Marco Pallecchi, Silvia Bua, Daniela Vullo, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Fabrizio Carta, Claudiu T. Supuran, Gianluca Bartolucci
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
ERMS
linear equations of deconvolution analysis
drug plasma stability
collision breakdown curves
matrix effects
Online Access:http://dx.doi.org/10.1080/14756366.2018.1445737

Internet

http://dx.doi.org/10.1080/14756366.2018.1445737

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