Control of cyclic oligoadenylate synthesis in a type III CRISPR system

Control of cyclic oligoadenylate synthesis in a type III CRISPR system

The CRISPR system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic elements. When viral RNA transcripts are detected, type III systems adopt an activated state that licenses DNA interference and synthesis of cyclic oligoadenylate (cOA). cOA activates...

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Bibliographic Details
Main Authors: Christophe Rouillon, Januka S Athukoralage, Shirley Graham, Sabine Grüschow, Malcolm F White
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
Sulfolobus solfataricus
archaea
CRISPR
Cas10
cyclic oligoadenylate
Online Access:https://elifesciences.org/articles/36734

Internet

https://elifesciences.org/articles/36734

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