Metronomic Chemotherapy Modulates Clonal Interactions to Prevent Drug Resistance in Non-Small Cell Lung Cancer

Metronomic Chemotherapy Modulates Clonal Interactions to Prevent Drug Resistance in Non-Small Cell Lung Cancer

Despite recent advances in deciphering cancer drug resistance mechanisms, relapse is a widely observed phenomenon in advanced cancers, mainly due to intratumor clonal heterogeneity. How tumor clones progress and impact each other remains elusive. In this study, we developed 2D and 3D non-small cell...

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Bibliographic Details
Main Authors: Maryna Bondarenko, Marion Le Grand, Yuval Shaked, Ziv Raviv, Guillemette Chapuisat, Cécile Carrère, Marie-Pierre Montero, Mailys Rossi, Eddy Pasquier, Manon Carré, Nicolas André
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
metronomic chemotherapy
intratumor heterogeneity
mathematical modeling
non-small cell lung cancer
glycolytic activity
lactate dehydrogenase
Online Access:https://www.mdpi.com/2072-6694/13/9/2239

Internet

https://www.mdpi.com/2072-6694/13/9/2239

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