Biophysical Analysis of Lipopolysaccharide Formulations for an Understanding of the Low Endotoxin Recovery (LER) Phenomenon

Biophysical Analysis of Lipopolysaccharide Formulations for an Understanding of the Low Endotoxin Recovery (LER) Phenomenon

Lipopolysaccharides (LPS, endotoxin) are complex and indispensable components of the outer membrane of most Gram-negative bacteria. They represent stimuli for many biological effects with pathophysiological character. Recombinant therapeutic proteins that are manufactured using biotechnological proc...

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Bibliographic Details
Main Authors: Wilmar Correa, Klaus Brandenburg, Ulrich Zähringer, Kishore Ravuri, Tarik Khan, Friedrich von Wintzingerode
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
endotoxin
lipopolysaccharide
Low Endotoxin Recovery
phase transitions
polysorbate
LPS aggregates
Small Angle X-ray Scattering
MAT
LAL and LER
Online Access:https://www.mdpi.com/1422-0067/18/12/2737

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https://www.mdpi.com/1422-0067/18/12/2737

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