<i>N</i>-(6-Chloro-3-nitropyridin-2-yl)-5-(1-methyl-1<i>H</i>-pyrazol-4-yl)isoquinolin-3-amine

<i>N</i>-(6-Chloro-3-nitropyridin-2-yl)-5-(1-methyl-1<i>H</i>-pyrazol-4-yl)isoquinolin-3-amine

Here we describe the synthesis of <i>N</i>-(6-chloro-3-nitropyridin-2-yl)5-(1-methyl-1<i>H</i>-pyrazol-4-yl)isoquinolin-3-amine via a three-step procedure including a Buchwald–Hartwig arylamination with benzophenone imine and a highly regioselective nucleophilic aromatic subs...

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Bibliographic Details
Main Authors: Valentin Wydra, Stefan Gerstenecker, Dieter Schollmeyer, Stanislav Andreev, Teodor Dimitrov, Ricardo Augusto Massarico Serafim, Stefan Laufer, Matthias Gehringer
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molbank
Subjects:
3-nitropyridines
nucleophilic aromatic substitution
Buchwald–Hartwig arylamination
protein kinase inhibitors
covalent inhibitors
Online Access:https://www.mdpi.com/1422-8599/2021/1/M1181

Internet

https://www.mdpi.com/1422-8599/2021/1/M1181

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