In silico models for evaluating proarrhythmic risk of drugs

Safety evaluation of drugs requires examination of the risk of generating Torsade de Pointes (TdP) because it can lead to sudden cardiac death. Until recently, the QT interval in the electrocardiogram (ECG) has been used in the evaluation of TdP risk because the QT interval is known to be associated...

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Bibliographic Details
Main Authors: Minki Hwang, Chul-Hyun Lim, Chae Hun Leem, Eun Bo Shim
Format: Article
Language:English
Published: AIP Publishing LLC 2020-06-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/1.5132618