Comparison of the Sulfonamide Inhibition Profiles of the β- and γ-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei

Comparison of the Sulfonamide Inhibition Profiles of the β- and γ-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei

We have cloned, purified, and characterized a β-carbonic anhydrase (CA, EC 4.2.1.1), BpsCAβ, from the pathogenic bacterium Burkholderia pseudomallei, responsible for the tropical disease melioidosis. The enzyme showed high catalytic activity for the physiologic CO2 hydration reaction to bicarbonate...

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Bibliographic Details
Main Authors: Daniela Vullo, Sonia Del Prete, Pietro Di Fonzo, Vincenzo Carginale, W. Alexander Donald, Claudiu T. Supuran, Clemente Capasso
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
carbonic anhydrase
metalloenzymes
pathogens
β-class
sulfonamide
Burkholderia pseudomallei
Online Access:http://www.mdpi.com/1420-3049/22/3/421

Internet

http://www.mdpi.com/1420-3049/22/3/421

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