Positive selection at codon 38 of the human <it>KCNE1 </it>(= <it>minK</it>) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes
<p>Abstract</p> <p>Background</p> <p>KCNE1 represents the regulatory beta-subunit of the slowly activating delayed rectifier potassium channel (IKs). Variants of KCNE1 have repeatedly been linked to the long-QT syndrome (LQTS), a disorder which predisposes to deafness,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-08-01
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| Series: | BMC Evolutionary Biology |
| Online Access: | http://www.biomedcentral.com/1471-2148/9/188 |