Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model

Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model

Abstract Background This study aims to explore the role of indoleamine-2,3-dioxygenase (IDO)/kynurenine (KYN) pathway of tryptophan (TRY) metabolism in behavioral alterations observed in hepatic encephalopathy (HE) rats. Methods Expression levels of proinflammatory cytokines were tested by QT-PCR an...

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Bibliographic Details
Main Authors: Xi Jiang, Lexing Xu, Lin Tang, Fuhe Liu, Ziwei Chen, Jiajia Zhang, Lei Chen, Cong Pang, Xuefeng Yu
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Neuroinflammation
Subjects:
Hepatic encephalopathy (HE)
Inflammation
Indoleamine-2,3-dioxygenase (IDO)
Serotonin (5-HT)
Depression
Anxiety
Online Access:http://link.springer.com/article/10.1186/s12974-017-1037-9

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http://link.springer.com/article/10.1186/s12974-017-1037-9

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