TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

The molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is sufficient to decrease energy expenditure and increase...

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Bibliographic Details
Main Authors: Yong Gao, Ting Yao, Zhuo Deng, Jong-Woo Sohn, Jia Sun, Yiru Huang, Xingxing Kong, Kai-jiang Yu, Rui-tao Wang, Hong Chen, Hongbo Guo, Jianqun Yan, Kathryn A. Cunningham, Yongsheng Chang, Tiemin Liu, Kevin W. Williams
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
melanocortin
obesity
diabetes
transient receptor potential cation channels
thermogenesis
glycemia
patch-clamp
electrophysiology
leptin
serotonin
lorcaserin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317946

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http://www.sciencedirect.com/science/article/pii/S2211124716317946

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