Plasma metabolomics of presymptomatic PSEN1‐H163Y mutation carriers: a pilot study

Abstract Background and Objective PSEN1‐H163Y carriers, at the presymptomatic stage, have reduced 18FDG‐PET binding in the cerebrum of the brain (Scholl et al., Neurobiol Aging 32:1388–1399, 2011). This could imply dysfunctional energy metabolism in the brain. In this study, plasma of presymptomatic...

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Bibliographic Details
Main Authors: Karthick Natarajan, Abbe Ullgren, Behzad Khoshnood, Charlotte Johansson, José M. Laffita‐Mesa, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Caroline Graff
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51296