Anti-Tat immunity defines CD4+ T-cell dynamics in people living with HIV on long-term cART.

Anti-Tat immunity defines CD4+ T-cell dynamics in people living with HIV on long-term cART.

Background: Low-level HIV viremia originating from virus reactivation in HIV reservoirs is often present in cART treated individuals and represents a persisting source of immune stimulation associated with sub-optimal recovery of CD4+ T cells. The HIV-1 Tat protein is released in the extracellular m...

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Bibliographic Details
Main Authors: Antonella Tripiciano, Orietta Picconi, Sonia Moretti, Cecilia Sgadari, Aurelio Cafaro, Vittorio Francavilla, Angela Arancio, Giovanni Paniccia, Massimo Campagna, Maria Rosaria Pavone-Cossut, Laura Sighinolfi, Alessandra Latini, Vito S. Mercurio, Massimo Di Pietro, Francesco Castelli, Annalisa Saracino, Cristina Mussini, Giovanni Di Perri, Massimo Galli, Silvia Nozza, Fabrizio Ensoli, Paolo Monini, Barbara Ensoli
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:EBioMedicine
Subjects:
HIV immune activation
HIV reservoirs
HIV residual viremia
CD4+ T cells
HIV-1 Tat
Anti-Tat antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000992

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http://www.sciencedirect.com/science/article/pii/S2352396421000992

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