Interleukin-17A Causes Osteoarthritis-Like Transcriptional Changes in Human Osteoarthritis-Derived Chondrocytes and Synovial Fibroblasts In Vitro

Interleukin-17A Causes Osteoarthritis-Like Transcriptional Changes in Human Osteoarthritis-Derived Chondrocytes and Synovial Fibroblasts In Vitro

Increased interleukin (IL)-17A has been identified in joints affected by osteoarthritis (OA), but it is unclear how IL-17A, and its family members IL-17AF and IL-17F, can contribute to human OA pathophysiology. Therefore, we aimed to evaluate the gene expression and signalling pathway activation eff...

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Bibliographic Details
Main Authors: Jolet Y. Mimpen, Mathew J. Baldwin, Adam P. Cribbs, Martin Philpott, Andrew J. Carr, Stephanie G. Dakin, Sarah J.B. Snelling
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
interleukin-17
cartilage
synovium
inflammation
transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.676173/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.676173/full

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