Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis

Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis

Summary: Distinct sub-assemblies (modules) of mitochondrial complex I (CI) are assembled with the assistance of CI Assembly Factors (CIAFs) through mechanisms that are incompletely defined. Here, using genetic analyses in Drosophila, we report that when either of the CIAFs – NDUFAF3 or NDUFAF4 – is...

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Bibliographic Details
Main Authors: Anjaneyulu Murari, Shauna-Kay Rhooms, Christian Garcia, Tong Liu, Hong Li, Bibhuti Mishra, Cassie Deshong, Edward Owusu-Ansah
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:iScience
Subjects:
molecular genetics
molecular mechanism of gene regulation
metabolic engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221008373

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http://www.sciencedirect.com/science/article/pii/S2589004221008373

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