3-Amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-chromeno [2,3-d ]pyrimidine: An Effecient Key Precursor for Novel Synthesis of Some Interesting Triazines and Triazepines as Potential Anti-Tumor Agents

3-Amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-chromeno [2,3-d ]pyrimidine: An Effecient Key Precursor for Novel Synthesis of Some Interesting Triazines and Triazepines as Potential Anti-Tumor Agents

A number of interesting heterocycles were prepared through interaction of the intermediate 3-amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-chromeno-[2,3-d]pyrimidine (1) and reagents such as hydrazonyl halides 2 to furnish triazine derivatives 4a–l. Reaction of 1 with phenacyl bromide aff...

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Bibliographic Details
Main Authors: Sobhi M. Gomha, Mohamed G. Badrey
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Molecules
Subjects:
pyrimidotriazines
pyrimidotriazepinones
triazolopyrimidines
antitumor activity
hydrazonoyl halides
Online Access:http://www.mdpi.com/1420-3049/17/10/11538

Internet

http://www.mdpi.com/1420-3049/17/10/11538

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