Pharmacophore and Molecular Docking Guided 3D-QSAR Study of Bacterial Enoyl-ACP Reductase (FabI) Inhibitors

Pharmacophore and Molecular Docking Guided 3D-QSAR Study of Bacterial Enoyl-ACP Reductase (FabI) Inhibitors

Enoyl acyl carrier protein (ACP) reductase (FabI) is a potential target for the development of antibacterial agents. Three-dimensional quantitative structure-activity relationships (3D-QSAR) for substituted formamides series of FabI inhibitors were investigated using comparative molecular field anal...

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Bibliographic Details
Main Authors: Qidong You, Ke Ding, Kun Huang, Man Lv, Xiaoyun Lu
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:International Journal of Molecular Sciences
Subjects:
FabI inhibitors
pharmacophore
molecular docking
3D-QSAR
CoMFA
CoMSIA
Online Access:http://www.mdpi.com/1422-0067/13/6/6620

Internet

http://www.mdpi.com/1422-0067/13/6/6620

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