Conventional and Chemically Programmed Asymmetric Bispecific Antibodies Targeting Folate Receptor 1

Conventional and Chemically Programmed Asymmetric Bispecific Antibodies Targeting Folate Receptor 1

T-cell engaging bispecific antibodies (biAbs) can mediate potent and specific tumor cell eradication in liquid cancers. Substantial effort has been invested in expanding this concept to solid cancers. To explore their utility in the treatment of ovarian cancer, we built a set of asymmetric biAbs in...

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Bibliographic Details
Main Authors: Junpeng Qi, David Hymel, Christopher G. Nelson, Terrence R. Burke, Christoph Rader
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
bispecific antibodies
catalytic antibodies
folate
FOLR1
CD3
ovarian cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01994/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01994/full

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