Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate

Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate

An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives and the heterocyclic benzoyl isosteres were synthesized via a novel aziridine intermediate. Following this met...

Full description

Bibliographic Details
Main Authors: Zhili Zhang, Chao Li, Ying Guo, Junyi Liu, Xiaowei Wang, Chao Tian, Shouxin Zhou
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:Molecules
Subjects:
tetrahydrofolate
aziridine
catalytic hydrogenation
solvent-free
Online Access:http://www.mdpi.com/1420-3049/17/5/5604

Internet

http://www.mdpi.com/1420-3049/17/5/5604

Similar Items