The Monocytes That Repopulate in Mice After Cyclophosphamide Treatment Acquire a Neutrophil Precursor Gene Signature and Immunosuppressive Activity

The Monocytes That Repopulate in Mice After Cyclophosphamide Treatment Acquire a Neutrophil Precursor Gene Signature and Immunosuppressive Activity

Cyclophosphamide (CTX) is a major component of the chemotherapy conditioning regimens used in the clinic to prepare cancer patients for hematopoietic stem cell transplantation or adoptive T cell therapy. Previous studies have shown that CTX given at nonmyeloablative doses in mice and patients leads...

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Bibliographic Details
Main Authors: Zhi-Chun Ding, Nada S. Aboelella, Locke Bryan, Huidong Shi, Gang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
chemotherapy
myeloid cell
monocyte
neutrophil
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.594540/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.594540/full

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