Systems-level G protein-coupled receptor therapy across a neurodegenerative continuum by the GLP-1 receptor system

Systems-level G protein-coupled receptor therapy across a neurodegenerative continuum by the GLP-1 receptor system

With our increasing appreciation of the true complexity of diseases and pathophysiologies it is clear that this knowledge needs to inform the future development of pharmacotherapeutics. For many disorders the disease mechanism itself is a complex process spanning multiple signaling networks, tissues...

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Bibliographic Details
Main Authors: Jonathan eJanssens, Harmonie eEtienne, Sherif eIdriss, Abdelkrim eAzmi, Bronwen eMartin, Stuart eMaudsley
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Endocrinology
Subjects:
GPCRs
pathophysiology
transcriptomics and proteomics
pharmacotherapeutics
Heptahelical G protein-coupled receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00142/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00142/full

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