Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G

Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G

Abstract Background Neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system, is often associated with retinal abnormalities including thinning of the retinal nerve fiber layer and microcystic changes. Here, we demonstrate that passive transfer of an anti-aquapori...

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Bibliographic Details
Main Authors: Christian M. Felix, Marc H. Levin, Alan S. Verkman
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Journal of Neuroinflammation
Subjects:
NMO
Retina
Müller cells
Aquaporin-4
Complement
Autoimmunity
Online Access:http://link.springer.com/article/10.1186/s12974-016-0746-9

Internet

http://link.springer.com/article/10.1186/s12974-016-0746-9

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