Ketamine Reverses Lateral Habenula Neuronal Dysfunction and Behavioral Immobility in the Forced Swim Test Following Maternal Deprivation in Late Adolescent Rats

Ketamine Reverses Lateral Habenula Neuronal Dysfunction and Behavioral Immobility in the Forced Swim Test Following Maternal Deprivation in Late Adolescent Rats

Mounting evidence suggests that the long-term effects of adverse early life stressors on vulnerability to drug addiction and mood disorders are related to dysfunction of brain monoaminergic signaling in reward circuits. Recently, there has been a growing interest in the lateral habenula (LHb) as LHb...

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Bibliographic Details
Main Authors: Ryan D. Shepard, Ludovic D. Langlois, Caroline A. Browne, Aylar Berenji, Irwin Lucki, Fereshteh S. Nugent
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
lateral habenula
LHb
ketamine
intrinsic excitability
early life stress
maternal deprivation
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2018.00039/full

Internet

https://www.frontiersin.org/article/10.3389/fnsyn.2018.00039/full

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