Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy

In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (<b>QN1</b>-<b>19</b>) and 13 dihydroquinolinones (<b>DQN1</b>-<b>13</b>) designed as potential multitarget small molecules (M...

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Bibliographic Details
Main Authors: Óscar M. Bautista-Aguilera, Lhassane Ismaili, Mourad Chioua, Rudolf Andrys, Monika Schmidt, Petr Bzonek, María Ángeles Martínez-Grau, Christopher D. Beadle, Tatiana Vetman, Francisco López-Muñoz, Isabel Iriepa, Bernard Refouvelet, Kamil Musilek, José Marco-Contelles
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
ChE/MAO inhibition
contilisant
dihydroquinolinones
docking
quinolinones
Online Access:https://www.mdpi.com/1422-0067/21/11/3913

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https://www.mdpi.com/1422-0067/21/11/3913

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