Subcutaneous Immunization with Fusion Protein DnaJ-ΔA146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4

Subcutaneous Immunization with Fusion Protein DnaJ-ΔA146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4

Subunit vaccines that are poorly immunogenic are often combined with adjuvants for immunization. Our previous research identified a pneumolysin variant (ΔA146Ply), a Toll-like receptor 4 agonist, that was an effective adjuvant in the protection of fusion protein DnaJ-ΔA146Ply against mucosal Strepto...

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Bibliographic Details
Main Authors: Yufeng Su, Dagen Li, Yan Xing, Hong Wang, Jian Wang, Jun Yuan, Xiaofang Wang, Fang Cui, Yibing Yin, Xuemei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
Streptococcus pneumoniae
DnaJ-ΔA146Ply
immune response
adjuvant
TLR4
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00686/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00686/full

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