Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

A library of thirty novel thiazolo[5,4-f]quinazolin-9(8H)-one derivatives belonging to four series designated as 12, 13, 14 and 15 was efficiently prepared, helped by microwave-assisted technology when required. The efficient multistep synthesis of methyl 6-amino-2-cyano- benzo[d]thiazole-7-carboxyl...

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Bibliographic Details
Main Authors: Damien Hédou, Julien Godeau, Nadège Loaëc, Laurent Meijer, Corinne Fruit, Thierry Besson
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
thiazolo[5,4-f]quinazolin-9(8H)-ones
multi-target-directed ligand
protein kinases
microwave-assisted synthesis
CDK5
GSK-3
CLK1
CK1
DYRK1A.
Online Access:http://www.mdpi.com/1420-3049/21/5/578

Internet

http://www.mdpi.com/1420-3049/21/5/578

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