c-Ki-ras oncogene amplification and FGF2 signaling pathways in the mouse Y1 adrenocortical cell line

c-Ki-ras oncogene amplification and FGF2 signaling pathways in the mouse Y1 adrenocortical cell line

The mouse Y1 adrenocortical tumor cell line is highly responsive to FGF2-(Fibroblast Growth Factor 2) and possesses amplified and over-expressed c-Ki-ras proto-oncogene. We previously reported that this genetic lesion leads to high constitutive levels of activation of the c-Ki-Ras-GTP->PI3K->A...

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Bibliographic Details
Main Authors: Forti Fábio L., Costa Érico T., Rocha Kátia M., Moraes Miriam S., Armelin Hugo A.
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2006-01-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
FGF2
adrenocortical tumor cells
c-ki-ras
c-h-ras
ERK
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000200005

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000200005

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