Synthesis of TPGS/Curcumin Nanoparticles by Thin-Film Hydration and Evaluation of Their Anti-Colon Cancer Efficacy In Vitro and In Vivo

Synthesis of TPGS/Curcumin Nanoparticles by Thin-Film Hydration and Evaluation of Their Anti-Colon Cancer Efficacy In Vitro and In Vivo

Curcumin (CCM) has many potential uses in anticancer chemotherapy, but its low water solubility poses a major problem, preventing its translation into clinical use. TPGS is a water-soluble derivative of vitamin E that acts as a surfactant with the ability to form micellar nanoparticles in water. Mor...

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Bibliographic Details
Main Authors: Hong Li, Liping Yan, Edith K.Y. Tang, Zhen Zhang, Wei Chen, Guohao Liu, Jingxin Mo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
curcumin
ROS
vitamin E TPGS
micellar nanoparticle
synergistic effects
colon cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00769/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00769/full

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