Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control

Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control

Objective: Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion and supplementation of neutral amino acids have been discussed as strategies to improve insulin sensitivity. Here we characterise...

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Bibliographic Details
Main Authors: Yang Jiang, Adam J. Rose, Tjeerd P. Sijmonsma, Angelika Bröer, Anja Pfenninger, Stephan Herzig, Dieter Schmoll, Stefan Bröer
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Molecular Metabolism
Subjects:
Type 2 diabetes
Epithelial transport
Amino acid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815000393

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http://www.sciencedirect.com/science/article/pii/S2212877815000393

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