Safety and Preliminary Efficacy of Lorcaserin for Cocaine Use Disorder: A Phase I Randomized Clinical Trial

Safety and Preliminary Efficacy of Lorcaserin for Cocaine Use Disorder: A Phase I Randomized Clinical Trial

Background and Objectives: Preclinical studies show serotonin (5-HT) 5-HT2C receptor (5-HT2CR) agonists reduce cocaine-seeking and cocaine intake. This study examined safety of the 5-HT2CR agonist lorcaserin administered with cocaine in participants with cocaine use disorder (CocUD). Secondarily, su...

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Bibliographic Details
Main Authors: Sade E. Johns, Lori Keyser-Marcus, Antonio Abbate, Edward Boone, Benjamin Van Tassell, Kathryn A. Cunningham, Noelle C. Anastasio, Justin L. Poklis, Tatiana Ramey, F. Gerard Moeller
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Psychiatry
Subjects:
cocaine
craving
safety
lorcaserin
visual analog scale
drug choice
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.666945/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2021.666945/full

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