New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]

Chronic infection by the obligate intracellular pathogen Mycobacterium leprae may lead to the development of leprosy. Of note, in the lepromatous clinical form of the disease, failure of the immune system to constrain infection allows the pathogen to reproduce to very high numbers with minimal clini...

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Bibliographic Details
Main Authors: Cristiana Santos de Macedo, Flavio Alves Lara, Roberta Olmo Pinheiro, Veronica Schmitz, Marcia de Berrêdo-Pinho, Geraldo Moura Pereira, Maria Cristina Vidal Pessolani
Format: Article
Language:English
Published: F1000 Research Ltd 2020-01-01
Series:F1000Research
Online Access:https://f1000research.com/articles/9-70/v1