Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy

Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy

The adoptive transfer of the chimeric antigen receptor (CAR) expressing T-cells has produced unprecedented successful results in the treatment of B-cell malignancies. However, the use of this technology in other malignancies remains less effective. In the setting of solid neoplasms, CAR T-cell metab...

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Bibliographic Details
Main Authors: Marsha Pellegrino, Francesca Del Bufalo, Biagio De Angelis, Concetta Quintarelli, Ignazio Caruana, Emmanuel de Billy
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
cancer
metabolic reprogramming
combined therapy
Chimeric Antigen Receptor T cells
immunotherapy
Online Access:https://www.mdpi.com/2073-4409/10/1/14

Internet

https://www.mdpi.com/2073-4409/10/1/14

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