Mutator suppression and escape from replication error-induced extinction in yeast.
Cells rely on a network of conserved pathways to govern DNA replication fidelity. Loss of polymerase proofreading or mismatch repair elevates spontaneous mutation and facilitates cellular adaptation. However, double mutants are inviable, suggesting that extreme mutation rates exceed an error thresho...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-10-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3188538?pdf=render |