A construction of 4,4-spirocyclic γ-lactams by tandem radical cyclization with carbon monoxide

A construction of 4,4-spirocyclic γ-lactams by tandem radical cyclization with carbon monoxide

A straightforward synthesis of 4,4-spirocyclic indol γ-lactams by tandem radical cyclization of iodoaryl allyl azides with CO was achieved. The reaction of iodoaryl allyl azides, TTMSS and AIBN under CO pressure (80 atm) in THF at 80 °C gave the desired 4,4-spirocyclic indoline, benzofuran, and oxin...

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Bibliographic Details
Main Authors: Mitsuhiro Ueda, Yoshitaka Uenoyama, Nozomi Terasoma, Shoko Doi, Shoji Kobayashi, Ilhyong Ryu, John A. Murphy
Format: Article
Language:English
Published: Beilstein-Institut 2013-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
4,4-spirocyclic indol γ-lactams
carbon monoxide
free radical
iodoaryl allyl azides
tandem radical cyclization
Online Access:https://doi.org/10.3762/bjoc.9.151

Internet

https://doi.org/10.3762/bjoc.9.151

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