Two approaches to the use of benzo[c][1,2]oxaboroles as active fragments for synthetic transformation of clarithromycin

Two approaches to the use of benzo[c][1,2]oxaboroles as active fragments for synthetic transformation of clarithromycin

Clarithromycin (active against Gram positive infections) and 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole derivatives (effective for Gram negative microbes) are the ligands of bacterial RNA. The antimicrobial activities of these benzoxaboroles linked with clarithromycin at 9 or 4″ position were compa...

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Bibliographic Details
Main Authors: Gennady B. Lapa, Elena P. Mirchink, Elena B Isakova, Maria N Preobrazhenskaya
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Antibiotic
macrolactone
macrolide
clarithromycin
benzoxaborole
1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole
antibacterial
conjugates of antibiotics
Online Access:http://dx.doi.org/10.1080/14756366.2016.1261129

Internet

http://dx.doi.org/10.1080/14756366.2016.1261129

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