Matrix degradability controls multicellularity of 3D cell migration

The fabrication of vascularized 3D tissues requires an understanding of how material properties govern endothelial cell invasion into the surrounding matrix. Here the authors integrate a non-swelling synthetic hydrogel with a microfluidic device to study chemokine gradient-driven angiogenic sproutin...

Full description

Bibliographic Details
Main Authors: Britta Trappmann, Brendon M. Baker, William J. Polacheck, Colin K. Choi, Jason A. Burdick, Christopher S. Chen
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00418-6