Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)

Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)

The eukaryotic polypyrimidine tract binding protein (PTB) serves primarily as a regulator of alternative splicing of messenger RNA, but is also co-opted to other roles such as RNA localisation and translation initiation from internal ribosome entry sites. The neuronal paralogue of PTB (nPTB) is 75%...

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Bibliographic Details
Main Authors: Amar Joshi, Vicent Esteve, Adrian N. Buckroyd, Markus Blatter, Frédéric H.-T. Allain, Stephen Curry
Format: Article
Language:English
Published: PeerJ Inc. 2014-03-01
Series:PeerJ
Subjects:
Polypyrimidine tract binding protein
Protein crystallography
Nuclear magnetic resonance spectroscopy
Pre-mRNA splicing
RNA binding proteins
Protein structure
Online Access:https://peerj.com/articles/305.pdf

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https://peerj.com/articles/305.pdf

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