Topoisomerase II alpha gene amplification is a favorable prognostic factor in patients with HER2-positive metastatic breast cancer treated with trastuzumab

Topoisomerase II alpha gene amplification is a favorable prognostic factor in patients with HER2-positive metastatic breast cancer treated with trastuzumab

<p>Abstract</p> <p>Background</p> <p>The vast majority of patients with HER2-positive metastatic breast cancer (MBC) treated with trastuzumab eventually develop resistance to this agent. There is an unmet need therefore, for identifying biological markers with possible...

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Bibliographic Details
Main Authors: Fountzilas George, Christodoulou Christos, Bobos Mattheos, Kotoula Vassiliki, Eleftheraki Anastasia G, Xanthakis Ioannis, Batistatou Anna, Pentheroudakis George, Xiros Nikolaos, Papaspirou Irene, Koumarianou Anna, Papakostas Pavlos, Bafaloukos Dimitrios, Skarlos Dimosthenis V, Kalogeras Konstantine T
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Journal of Translational Medicine
Subjects:
Breast cancer
Topoisomerase II alpha
Fluorescence in situ hybridization
Gene amplification
Trastuzumab
Prognostic factors
Anthracyclines
Predictive factors
Online Access:http://www.translational-medicine.com/content/10/1/212

Internet

http://www.translational-medicine.com/content/10/1/212

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