High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans

High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans

The Genome Aggregation Database presently contains >120,000 human genomes. We searched in this database for the presence of mutations at the sites of tetanus (TeNT) and botulinum neurotoxins (BoNTs) cleavages of the three SNARE proteins: VAMP, SNAP-25 and Syntaxin. These mutations could accou...

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Bibliographic Details
Main Authors: Stefan Carle, Marco Pirazzini, Ornella Rossetto, Holger Barth, Cesare Montecucco
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Toxins
Subjects:
ExAC
gnomAD
botulinum neurotoxin
tetanus neurotoxin
SNAP-25
VAMP-1/2
syntaxin-1A/1B
Online Access:https://www.mdpi.com/2072-6651/9/12/404

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https://www.mdpi.com/2072-6651/9/12/404

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