Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing

Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing

Abstract Objectives Complete deficiency of alternative pathway (AP) complement factors, explained by homozygous mutations, is a well‐known risk factor for invasive bacterial infections; however, this is less obvious for heterozygous mutations. We describe two siblings with a heterozygous NM_001928.3...

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Bibliographic Details
Main Authors: Jeroen D Langereis, Renate G van derMolen, Corrie deKat Angelino, Stefanie S Henriet, Marien I deJonge, Irma Joosten, Annet Simons, Janneke HM Schuurs‐Hoeijmakers, Marcel vanDeuren, Koen vanAerde, Michiel van derFlier
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
complement
factor D
haplodeficiency
immunodeficiency
infection
vaccination
Online Access:https://doi.org/10.1002/cti2.1256

Internet

https://doi.org/10.1002/cti2.1256

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