SYSTEMIC INFLAMMATION IMPAIRS ATTENTION AND COGNITIVE FLEXIBILITY BUT NOT ASSOCIATIVE LEARNING IN AGED RATS: Possible Implications for Delirium

SYSTEMIC INFLAMMATION IMPAIRS ATTENTION AND COGNITIVE FLEXIBILITY BUT NOT ASSOCIATIVE LEARNING IN AGED RATS: Possible Implications for Delirium

Delirium is a common and morbid condition in elderly hospitalized patients. Its pathophysiology is poorly understood but inflammation has been implicated based on a clinical association with systemic infection and surgery and preclinical data showing that systemic inflammation adversely affects hipp...

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Bibliographic Details
Main Authors: Deborah J Culley, Mary eSnayd, Mark G Baxter, Zhongcong eXie, In-Ho eLee, James eRudolph, Sharon eInouye, Edward eMarcantonio, Gregory eCrosby
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Lipopolysaccharides
Rats
frontal cortex
aging neuroscience
Inflammation.
set shifting
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00107/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00107/full

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