Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation.

The unfolded protein response (UPR) in the endoplasmic reticulum (ER) and the cytoplasmic heat stress response are two major stress response systems necessary for maintaining proteostasis for cellular health. Failure of either of these systems, such as in sustained UPR activation or in insufficient...

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Bibliographic Details
Main Authors: Eunhee Kim, Kazuko Sakata, Francesca-Fang Liao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5517072?pdf=render